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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
14/06/2022 |
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Actualizado : |
14/06/2022 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
JARA, E.; PEÑAGARICANO, F.; ARMSTRONG, E.; CIAPPESONI, G.; IRIARTE, A.; NAVAJAS, E. |
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Afiliación : |
EUGENIO JARA, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, Montevideo 11600, Uruguay; FRANCISCO PEÑAGARICANO, Department of Animal and Dairy Sciences, University of Wisconsin-Madison, Madison, WI 53706, United State; EILEEN ARMSTRONG, Unidad de Genética y Mejora Animal, Departamento de Producción Animal, Facultad de Veterinaria, Universidad de la República, 11600, Montevideo, Uruguay; CARLOS GABRIEL CIAPPESONI SCARONE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRÉS IRIARTE, Laboratorio de Biología Computacional, Departamento de Desarrollo Biotecnológico, Instituto de Higiene, Facultad de Medicina, Universidad de la República, 11600, Montevideo, Uruguay; ELLY ANA NAVAJAS VALENTINI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Revealing the genetic basis of eyelid pigmentation in Hereford cattle. |
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Fecha de publicación : |
2022 |
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Fuente / Imprenta : |
Journal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110 |
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ISSN : |
1525-3163 |
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DOI : |
10.1093/jas/skac110 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022.
Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com -- |
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Contenido : |
ABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022. MenosABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed se... Presentar Todo |
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Palabras claves : |
Beef cattle; Melanocyte biology; Ocular pathologies. |
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Asunto categoría : |
L01 Ganadería |
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Marc : |
LEADER 03180naa a2200253 a 4500
001 1063291
005 2022-06-14
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022 $a1525-3163
024 7 $a10.1093/jas/skac110$2DOI
100 1 $aJARA, E.
245 $aRevealing the genetic basis of eyelid pigmentation in Hereford cattle.$h[electronic resource]
260 $c2022
500 $aArticle history: Received December 14, 2021; Accepted April 4, 2022; Advance access publication 7 April 2022. Corresponding author: Eugenio Jara, email: eugeniojara19@gmail.com --
520 $aABSTRACT - Ocular squamous cell carcinoma and infectious keratoconjunctivitis are common ocular pathologies in Hereford cattle with considerable economic impact. Both pathologies have been associated with low eyelid pigmentation, and thus, genetic selection for higher eyelid pigmentation could reduce their incidence. The objective of the present study was to reveal the genetic basis of eyelid pigmentation in Hereford cattle. The analysis included a single-step genome-wide association study (ssGWAS) and a subsequent gene-set analysis in order to identify individual genes, genetic mechanisms, and biological pathways implicated in this trait. Data consisted of eyelid pigmentation records in 1,165 Hereford bulls and steers, visually assessed in five categories between 0% and 100%. Genotypic data for 774,660 single-nucleotide polymorphism markers were available for 886 animals with pigmentation records. Pedigree information of three generations of ancestors of animals with phenotype was considered in this study, with a total of 4,929 animals. Our analyses revealed that eyelid pigmentation is a moderately heritable trait, with heritability estimates around 0.41. The ssGWAS identified at least eight regions, located on BTA1, BTA3, BTA5, BTA14, BTA16, BTA18, BTA19, and BTA24, associated with eyelid pigmentation. These regions harbor genes that are directly implicated in melanocyte biology and skin pigmentation, such as ADCY8, PLD1, KITLG, and PRKCA. The gene-set analysis revealed several functional terms closely related to melanogenesis, such as positive regulation of melanocyte differentiation and regulation of ERK1 and ERK2 cascade. Overall, our findings provide evidence that eyelid pigmentation is a heritable trait influenced by many loci. Indeed, the ssGWAS detected several candidate genes that are directly implicated in melanocyte biology, including melanogenesis. This study contributes to a better understanding of the genetic and biological basis of eyelid pigmentation and presents novel information that could aid to design breeding strategies for reducing the incidence of ocular pathologies in cattle. Additional research on the genetic link between eyelid pigmentation and ocular pathologies is needed. © The Author(s) 2022.
653 $aBeef cattle
653 $aMelanocyte biology
653 $aOcular pathologies
700 1 $aPEÑAGARICANO, F.
700 1 $aARMSTRONG, E.
700 1 $aCIAPPESONI, G.
700 1 $aIRIARTE, A.
700 1 $aNAVAJAS, E.
773 $tJournal of Animal Science, 2022, Volume 100, Issue 5. doi: https://doi.org/10.1093/jas/skac110
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Registro original : |
INIA Las Brujas (LB) |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
25/10/2016 |
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Actualizado : |
25/10/2016 |
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Tipo de producción científica : |
Poster |
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Autor : |
AGUERRE, V.; ALBICETTE, M.M.; BORTAGARAY, I.; BLUMETTO, O.; CARDOZO, G.; CASTAGNA, A.; CLARA, P.; GARCIA, F.; GILSANZ, J.C.; LEONI, C.; QUINTANS, G.; RUGGIA, A.; SCARLATO, M.; SCARLATO, S.; TISCORNIA, G.; VILARO, F.; DOGLIOTTI, S.; ALBIN, A. |
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Afiliación : |
MARIA VERONICA AGUERRE ANTIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIA MARTA ALBICETTE BASTRERI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ISABEL BORTAGARAY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; OSCAR RICARDO BLUMETTO VELAZCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GERONIMO AGUSTIN CARDOZO CABANELAS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDRES CASTAGNA DU PRE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO DANIEL CLARA PEREZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FELIPE LUIS GARCIA OLASO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JUAN CARLOS GILSANZ MARTINEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINA LEONI VELAZCO, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GRACIELA QUINTANS ILARIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ANDREA PAOLA RUGGIA CHIESA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; MARIANA SCARLATO GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SANTIAGO SCARLATO GARCIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GUADALUPE TISCORNIA TOSAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FRANCISCO LUIS VILARO PAREJA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SANTIAGO DOGLIOTTI, Universidad de la República (UdelaR)/ Facultad de Agronomía; ALFREDO SANTIAGO ALBIN FERREIRA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Co-innovando para el desarrollo sostenible de sistemas de producción familiar de Rocha-Uruguay: avances sobre la dimensión social del cambio y la comprensión del tipo de procesos de aprendizaje. [Poster] |
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Fecha de publicación : |
2014 |
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Fuente / Imprenta : |
In: CONGRESO DE CIENCIAS SOCIALES Y AGRARIAS, 2. "Enfoques y alternativas para el desarrollo rural", Salto (UY): Fac.Agronomía, Regional Norte (UdelaR), 6-8 Agosto 2014. [Poster] |
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Páginas : |
1 p. |
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Idioma : |
Español |
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Palabras claves : |
CO-INNOVACIÓN; SISTEMAS DE PRODUCCIÓN FAMILIAR. |
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Thesagro : |
AGRICULTURA FAMILIAR. |
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Asunto categoría : |
-- |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/6229/1/Aguerre-V.-2014.-poster-CCSS-II-INIA.pdf
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Marc : |
LEADER 01221nam a2200349 a 4500
001 1055885
005 2016-10-25
008 2014 bl uuuu u00u1 u #d
100 1 $aAGUERRE, V.
245 $aCo-innovando para el desarrollo sostenible de sistemas de producción familiar de Rocha-Uruguay$bavances sobre la dimensión social del cambio y la comprensión del tipo de procesos de aprendizaje. [Poster]$h[electronic resource]
260 $aIn: CONGRESO DE CIENCIAS SOCIALES Y AGRARIAS, 2. "Enfoques y alternativas para el desarrollo rural", Salto (UY): Fac.Agronomía, Regional Norte (UdelaR), 6-8 Agosto 2014. [Poster]$c2014
300 $a1 p.
650 $aAGRICULTURA FAMILIAR
653 $aCO-INNOVACIÓN
653 $aSISTEMAS DE PRODUCCIÓN FAMILIAR
700 1 $aALBICETTE, M.M.
700 1 $aBORTAGARAY, I.
700 1 $aBLUMETTO, O.
700 1 $aCARDOZO, G.
700 1 $aCASTAGNA, A.
700 1 $aCLARA, P.
700 1 $aGARCIA, F.
700 1 $aGILSANZ, J.C.
700 1 $aLEONI, C.
700 1 $aQUINTANS, G.
700 1 $aRUGGIA, A.
700 1 $aSCARLATO, M.
700 1 $aSCARLATO, S.
700 1 $aTISCORNIA, G.
700 1 $aVILARO, F.
700 1 $aDOGLIOTTI, S.
700 1 $aALBIN, A.
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